Okay....a very interesting question for you all. So in my current run, I tried to avoid going into the Natalie route; for this reason I kinda avoided going to the dinner with Natalie. Then, I figured out during the run, for me to get the transformations, I would need the Slime Queen Core. So I went for the dinner, but for a reason I jumped straight into the event of First base (namely the kiss). Now there is no way for me to get the optional quest, since everytime I see Catherine the only option is Bye (she should be missing for the mission to start). Also, I have noticed that there is currently no way to go a Love run with any other girl other then with Natalie, If you pursue the transformations for Breast Growth transformation and penis reduction tf ; if I understand it soft locks you into this route or not?
Anyhow...seems like I will need to make a new run....that will throw me into Natalie route again...to get the necessesary core, even though this is something I dont want.